Table 1 Mannose-binding lectin 2 (MBL2) gene polymorphisms in patients with infrequent and frequent exacerbation
Single nucleotide polymorphisms | Infrequent exacerbation n (%) | Frequent exacerbation n (%) | p value |
|---|---|---|---|
Promoter region | Â | Â | Â |
HL (−550 G > C; rs11003125) |  |  | 0.03 |
C/C (L/L) | 77 (50.0) | 46 (37.4) | Â |
G/C (H/L) | 57 (37.0) | 48 (39.0) | Â |
G/G (H/H) | 20 (13.0) | 29 (23.6) | Â |
YX (−221 G > C; rs7096206) |  |  | 0.64 |
G/G (Y/Y) | 92 (59.7) | 80 (65.0) | Â |
G/C (Y/X) | 53 (34.4) | 36 (29.3) | Â |
C/C (X/X) | 9 (5.8) | 7 (5.7) | Â |
Exon 1 | Â | Â | Â |
PQ (+4 C > T; rs7095891) |  |  | 0.65 |
C/C (P/P) | 89 (57.8) | 77 (62.6) | Â |
C/T (P/Q) | 47 (30.5) | 35 (28.5) | Â |
T/T (Q/Q) | 18 (11.7) | 11 (8.9) | Â |
A/D (+223 C > T; rs5030737) |  |  | 0.03 |
A/A (C/C) | 124 (91.9) | 119 (83.8) | Â |
A/D (C/T) | 12 (7.8) | 21 (17.1) | Â |
D/D (T/T) | 0 (0) | 1 (0.8) | Â |
A/B (+230 G > A; rs1800450) |  |  |  |
A/A (G/G) | 129 (83.8) | 106(86.2) | 0.79 |
A/B (G/A) | 23 (14.9) | 15 (12.2) | Â |
B/B (A/A) | 2 (1.3) | 2 (1.6) | Â |
A/C (+239 G > A; rs1800451) |  |  |  |
A/A (G/G) | 146 (94.8) | 119 (96.7) | 0.27 |
A/C (G/C) | 8 (5.2) | 3 (2.4) | Â |
C/C (A/A) | 0 (0) | 1 (0.8) | Â |