Critical role of actin-associated proteins in smooth muscle contraction, cell proliferation, airway hyperresponsiveness and airway remodeling

Table 1 The expression and role of actin-associated proteins in different cell-types and species

Name	Cell types	Species	Role	References
Abi1	ASMCs, VSMCs	Human	Adapter protein	[17]
Abl	ASMCs, VSMCs	Human, rat, mouse	Tyrosine kinase	[5, 17, 47, 48]
Arp2/3	ASMCs, VSMCs	Human, rat, canine	Promote actin branching	[17, 48, 54]
CAS	ASMCs, VSMCs	Human, rat	Adapter protein	[17, 48]
Cdc42	ASMCs	Canine	Small GTPase	[11, 27, 28]
Cofilin	ASMCs	Canine	Actin regulator	[45]
Cortactin	ASMCs	Human	Adapter protein	[18, 125]
CrkII	ASMCs	Canine	Adapter protein	[27]
FAK	ASMCs	Canine	Tyrosine kinase	[87, 88]
GMF-γ	ASMCs	Human	Promote actin debranching	[16]
HDAC8	ASMCs	Human, mouse	Histone deacetylase	[111]
HSP27	ASMCs	Canine	Heat shock protein	[53]
ILK	ASMCs	Canine	Adapter protein, kinase	[11, 55]
Integrin-β₁	ASMCs	Human, canine	Link ECM to actin cytoskeleton	[52, 55]
N-Cadherin	ASMCs	Human	Adherens junction protein	[58]
N-WASP	ASMCs, VSMCs	Human, rat, canine	Promote actin nucleation	[17, 48, 55]
p38MAPK	ASMCs	Canine	Serine/threonine kinase	[93]
PAK1	ASMCs	Canine, mouse, human	Serine/threonine kinase	[80, 93, 131]
Parvin	ASMCs	Canine	Actin binding protein	[55]
Paxillin	ASMCs	Canine	Adapter protein	[55, 82, 83]
PINCH	ASMCs	Canine	ILK binding partner	[11, 55]
Profilin	ASMCs, VSMCs	Human, canine	Promote actin transport	[18, 32]
RhoA	ASMCs	Canine, human	Small GTPase	[30, 104]
Talin	ASMCs	Canine	Structural protein	[29, 51]
VASP	ASMCs	Canine	Phosphoprotein	[44]
Vinculin	ASMCs	Canine	Structural protein	[29, 51]
α-Actinin	ASMCs	Canine	Cross linking protein	[52]
β-Catenin	ASMCs	Human	Adherens junction protein	[58]

ISSN: 1465-993X