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Table 1 The expression and role of actin-associated proteins in different cell-types and species

From: Critical role of actin-associated proteins in smooth muscle contraction, cell proliferation, airway hyperresponsiveness and airway remodeling

Name Cell types Species Role References
Abi1 ASMCs, VSMCs Human Adapter protein [17]
Abl ASMCs, VSMCs Human, rat, mouse Tyrosine kinase [5, 17, 47, 48]
Arp2/3 ASMCs, VSMCs Human, rat, canine Promote actin branching [17, 48, 54]
CAS ASMCs, VSMCs Human, rat Adapter protein [17, 48]
Cdc42 ASMCs Canine Small GTPase [11, 27, 28]
Cofilin ASMCs Canine Actin regulator [45]
Cortactin ASMCs Human Adapter protein [18, 125]
CrkII ASMCs Canine Adapter protein [27]
FAK ASMCs Canine Tyrosine kinase [87, 88]
GMF-γ ASMCs Human Promote actin debranching [16]
HDAC8 ASMCs Human, mouse Histone deacetylase [111]
HSP27 ASMCs Canine Heat shock protein [53]
ILK ASMCs Canine Adapter protein, kinase [11, 55]
Integrin-β1 ASMCs Human, canine Link ECM to actin cytoskeleton [52, 55]
N-Cadherin ASMCs Human Adherens junction protein [58]
N-WASP ASMCs, VSMCs Human, rat, canine Promote actin nucleation [17, 48, 55]
p38MAPK ASMCs Canine Serine/threonine kinase [93]
PAK1 ASMCs Canine, mouse, human Serine/threonine kinase [80, 93, 131]
Parvin ASMCs Canine Actin binding protein [55]
Paxillin ASMCs Canine Adapter protein [55, 82, 83]
PINCH ASMCs Canine ILK binding partner [11, 55]
Profilin ASMCs, VSMCs Human, canine Promote actin transport [18, 32]
RhoA ASMCs Canine, human Small GTPase [30, 104]
Talin ASMCs Canine Structural protein [29, 51]
VASP ASMCs Canine Phosphoprotein [44]
Vinculin ASMCs Canine Structural protein [29, 51]
α-Actinin ASMCs Canine Cross linking protein [52]
β-Catenin ASMCs Human Adherens junction protein [58]
  1. ASMCs airway smooth muscle cells, VASMCs vascular smooth muscle cells