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Fig. 4 | Respiratory Research

Fig. 4

From: Critical role of actin-associated proteins in smooth muscle contraction, cell proliferation, airway hyperresponsiveness and airway remodeling

Fig. 4

Regulation of MAPK pathway and cytokinesis by Abl. Upon the binding of ligands to growth factor receptors, Abl promotes Raf-1 activation by controlling actin dynamics, which in turn modulates the activation of MEK and ERK. In addition, Abl is recruited to the midzone during cytokinesis, which mediates cortactin phosphorylation. Phosphorylated cortactin promotes F-actin assembly, which facilitates contractile ring formation and cytokinesis

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Respiratory Research

ISSN: 1465-993X

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