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Fig. 1 | Respiratory Research

Fig. 1

From: Critical role of actin-associated proteins in smooth muscle contraction, cell proliferation, airway hyperresponsiveness and airway remodeling

Fig. 1

Mechanisms of Abl-regulated actin polymerization. Stimulation with agonists such as acetylcholine may activate Abl tyrosine kinase, which regulates the formation of the multiprotein complex including Crk-associated substrate (CAS), the adapter protein Abi1 (Abl interactor 1) and N-WASP (neuronal Wiskott-Aldrich Syndrome Protein), which in turn activates N-WASP, actin polymerization and smooth muscle contraction. Activated Abl also catalyzes phosphorylation of GMF-γ (glia maturation factor-γ) at Tyr-104, which induces the dissociation of GMF-γ from Arp2/3, and promotes actin polymerization. Furthermore, contractile agonists promote the association of cortactin (CTTN) with profilin-1 (Pfn-1), which induces actin polymerization and smooth muscle contraction. The interaction of cortactin with Pfn-1 is regulated by cortactin phosphorylation and Abl tyrosine kinase

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Respiratory Research

ISSN: 1465-993X

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