Hazard ratio (95 % CI) | |||
---|---|---|---|
LAMA | LABA | LABA+ICS | |
Time to first moderate-severe exacerbation | |||
Age (years) | NS | NS | 1.01 (1.00-1.02) |
Gender (Male vs Female) | 0.59 (0.42-0.83) | NS | NS |
COPD incident case (Yes vs No) | 2.08 (1.05-4.13) | NS | NS |
Number of moderate to severe exacerbations at baseline | |||
1 vs 0 | 2.11 (1.43-3.11) | NS | 1.78 (1.41-2.25) |
≥2 vs 0 | 5.00 (3.21-7.79) | NS | 3.41 (2.73-4.26) |
Number of non-COPD hospitalisations at baseline | |||
1 vs 0 | NS | 1.19 (0.40-3.52) | NS |
≥2 vs 0 | NS | 15.87 (4.80-52.52) | NS |
Time to first severe exacerbation | |||
MPR (≥80 % vs <80 %) | NS | NS | 1.60 (1.17-2.19) |
Age (years) | NS | NS | 1.02 (1.01-1.04) |
GP visits | NS | NS | 1.01 (1.00-1.01) |
SABD ≥4 vs 0 | NS | NS | 1.39 (1.02-1.89) |
Number of moderate to severe exacerbations at baseline | |||
1 vs 0 | 1.65 (0.92-2.96) | NS | NS |
≥2 vs 0 | 2.52 (1.29-4.91) | NS | NS |
Number of non-COPD related hospitalisations at baseline | |||
1 vs 0 | 3.32 (1.75-6.30) | NS | 1.81 (1.23-2.66) |
≥2 vs 0 | 3.12 (1.51-6.45) | NS | 1.71 (1.08-2.70) |