LABD | ||||
---|---|---|---|---|
LABA | LAMA | LABA+LAMA | LABA+ICS | |
(N = 1317) | (N = 6695) | (N = 271) | (N = 9246) | |
Gender, male (%) | 53 | 57 | 60 | 52 |
Age at index date, Mean (SD) | 68.6 (10.8) | 69.3 (10.4) | 68.2 (9.8) | 68.4 (11.4) |
Comorbidity (%)a | ||||
Cancer | 9 | 10 | 10 | 10 |
Congestive heart disease | 5 | 6 | 4 | 5 |
Dementia | 1 | 1 | 0 | 1 |
Diabetes | 13 | 13 | 11 | 13 |
Peripheral vascular disease | 9 | 9 | 8 | 7 |
Renal disease | 17 | 17 | 14 | 16 |
Anxiety | 17 | 17 | 11 | 17 |
Asthma | 16 | 13 | 15 | 38 |
Depression | 16 | 14 | 14 | 14 |
Heart failure | 6 | 7 | 4 | 7 |
Myocardial infarction | 8 | 10 | 8 | 8 |
Stroke | 5 | 6 | 3 | 5 |
Mean CCI (SD) | 1.5 (0.9) | 1.6 (0.9) | 1.3 (0.7) | 1.5 (0.9) |
Smoking status (%)b | ||||
Ex-smoker + never smoker | 50 | 48 | 52 | 52 |
Current smoker | 42 | 47 | 40 | 38 |
Unknown | 8 | 6 | 8 | 10 |
BMI, Mean (SD)bc | 27.8 (6.0) | 27.2 (6.2) | 27.5 (5.7) | 27.7 (6.5) |
Dyspnea (%)b d | ||||
MRC < 3 | 59 | 55 | 48 | 57 |
MRC ≥ 3 | 41 | 45 | 52 | 43 |
Airflow limitation (%)be | ||||
FEV1 ≥ 80 % | 15 | 12 | 10 | 14 |
FEV1 50-79 % | 64 | 61 | 64 | 52 |
FEV1 30-49 % | 19 | 25 | 22 | 27 |
FEV1 < 30 % | 2 | 3 | 5 | 4 |
Disease burden [rate per patient year (95 % CI)]f | ||||
Any exacerbations (Moderate to severe) | 0.49 (0.45-0.53) | 0.49 (0.47-0.51) | 0.47 (0.39-0.56) | 0.70 (0.68-0.71) |
Hospitalised (severe) exacerbations | 0.07 (0.06-0.08) | 0.09 (0.08-0.10) | 0.10 (0.07-0.14) | 0.12 (0.12-0.13) |
Non COPD hospitalizations | 0.36 (0.33-0.40) | 0.39 (0.37-0.40) | 0.39 (0.32-0.47) | 0.42 (0.40-0.43) |
Patients with more than 4 SABD prescriptions (%) | 25 | 20 | 21 | 29 |