TY - JOUR AU - Salathe, M. PY - 2007 DA - 2007// TI - Regulation of mammalian ciliary beating JO - Annu Rev Physiol VL - 69 UR - https://doi.org/10.1146/annurev.physiol.69.040705.141253 DO - 10.1146/annurev.physiol.69.040705.141253 ID - Salathe2007 ER - TY - JOUR AU - Matsui, H. AU - Grubb, B. R. AU - Tarran, R. AU - Randell, S. H. AU - Gatzy, J. T. AU - Davis, C. W. AU - Boucher, R. C. PY - 1998 DA - 1998// TI - Evidence for periciliary liquid layer depletion, not abnormal ion composition, in the pathogenesis of cystic fibrosis airways disease JO - Cell VL - 95 UR - https://doi.org/10.1016/S0092-8674(00)81724-9 DO - 10.1016/S0092-8674(00)81724-9 ID - Matsui1998 ER - TY - JOUR AU - Maurice, D. H. AU - Ke, H. AU - Ahmad, F. AU - Wang, Y. AU - Chung, J. AU - Manganiello, V. C. PY - 2014 DA - 2014// TI - Advances in targeting cyclic nucleotide phosphodiesterases JO - Nat Rev Drug Discov VL - 13 UR - https://doi.org/10.1038/nrd4228 DO - 10.1038/nrd4228 ID - Maurice2014 ER - TY - JOUR AU - Zhang, K. Y. AU - Ibrahim, P. N. AU - Gillette, S. AU - Bollag, G. PY - 2005 DA - 2005// TI - Phosphodiesterase-4 as a potential drug target JO - Expert Opin Ther Targets VL - 9 UR - https://doi.org/10.1517/14728222.9.6.1283 DO - 10.1517/14728222.9.6.1283 ID - Zhang2005 ER - TY - JOUR AU - Michalski, J. M. AU - Golden, G. AU - Ikari, J. AU - Rennard, S. I. PY - 2012 DA - 2012// TI - PDE4: a novel target in the treatment of chronic obstructive pulmonary disease JO - Clin Pharmacol Ther VL - 91 UR - https://doi.org/10.1038/clpt.2011.266 DO - 10.1038/clpt.2011.266 ID - Michalski2012 ER - TY - JOUR AU - Giembycz, M. A. AU - Field, S. K. PY - 2010 DA - 2010// TI - Roflumilast: first phosphodiesterase 4 inhibitor approved for treatment of COPD JO - Drug Des Devel Ther VL - 4 ID - Giembycz2010 ER - TY - JOUR AU - Dransfield, M. T. AU - Wilhelm, A. M. AU - Flanagan, B. AU - Courville, C. AU - Tidwell, S. L. AU - Raju, S. V. AU - Gaggar, A. AU - Steele, C. AU - Tang, L. P. AU - Liu, B. AU - Rowe, S. M. PY - 2013 DA - 2013// TI - Acquired cystic fibrosis transmembrane conductance regulator dysfunction in the lower airways in COPD JO - Chest VL - 144 UR - https://doi.org/10.1378/chest.13-0274 DO - 10.1378/chest.13-0274 ID - Dransfield2013 ER - TY - JOUR AU - Sloane, P. A. AU - Shastry, S. AU - Wilhelm, A. AU - Courville, C. AU - Tang, L. P. AU - Backer, K. AU - Levin, E. AU - Raju, S. V. AU - Li, Y. AU - Mazur, M. PY - 2012 DA - 2012// TI - A pharmacologic approach to acquired cystic fibrosis transmembrane conductance regulator dysfunction in smoking related lung disease JO - PLoS One VL - 7 UR - https://doi.org/10.1371/journal.pone.0039809 DO - 10.1371/journal.pone.0039809 ID - Sloane2012 ER - TY - JOUR AU - Raju, S. V. AU - Jackson, P. L. AU - Courville, C. A. AU - McNicholas, C. M. AU - Sloane, P. A. AU - Sabbatini, G. AU - Tidwell, S. AU - Tang, L. P. AU - Liu, B. AU - Fortenberry, J. A. PY - 2013 DA - 2013// TI - Cigarette smoke induces systemic defects in cystic fibrosis transmembrane conductance regulator function JO - Am J Respir Crit Care Med VL - 188 UR - https://doi.org/10.1164/rccm.201304-0733OC DO - 10.1164/rccm.201304-0733OC ID - Raju2013 ER - TY - JOUR AU - Cobb, B. R. AU - Fan, L. AU - Kovacs, T. E. AU - Sorscher, E. J. AU - Clancy, J. P. PY - 2003 DA - 2003// TI - Adenosine receptors and phosphodiesterase inhibitors stimulate Cl- secretion in Calu-3 cells JO - Am J Respir Cell Mol Biol VL - 29 UR - https://doi.org/10.1165/rcmb.2002-0247OC DO - 10.1165/rcmb.2002-0247OC ID - Cobb2003 ER - TY - JOUR AU - Fuhrmann, M. AU - Jahn, H. U. AU - Seybold, J. AU - Neurohr, C. AU - Barnes, P. J. AU - Hippenstiel, S. AU - Kraemer, H. J. AU - Suttorp, N. PY - 1999 DA - 1999// TI - Identification and function of cyclic nucleotide phosphodiesterase isoenzymes in airway epithelial cells JO - Am J Respir Cell Mol Biol VL - 20 UR - https://doi.org/10.1165/ajrcmb.20.2.3140 DO - 10.1165/ajrcmb.20.2.3140 ID - Fuhrmann1999 ER - TY - JOUR AU - Bernacki, S. H. AU - Nelson, A. L. AU - Abdullah, L. AU - Sheehan, J. K. AU - Harris, A. AU - Davis, C. W. AU - Randell, S. H. PY - 1999 DA - 1999// TI - Mucin gene expression during differentiation of human airway epithelia in vitro. Muc4 and muc5b are strongly induced JO - Am J Respir Cell Mol Biol VL - 20 UR - https://doi.org/10.1165/ajrcmb.20.4.3442 DO - 10.1165/ajrcmb.20.4.3442 ID - Bernacki1999 ER - TY - JOUR AU - Schmid, A. AU - Bai, G. AU - Schmid, N. AU - Zaccolo, M. AU - Ostrowski, L. E. AU - Conner, G. E. AU - Fregien, N. AU - Salathe, M. PY - 2006 DA - 2006// TI - Real-time analysis of cAMP-mediated regulation of ciliary motility in single primary human airway epithelial cells JO - J Cell Sci VL - 119 UR - https://doi.org/10.1242/jcs.03181 DO - 10.1242/jcs.03181 ID - Schmid2006 ER - TY - JOUR AU - Nlend, M. C. AU - Bookman, R. J. AU - Conner, G. E. AU - Salathe, M. PY - 2002 DA - 2002// TI - Regulator of G-protein signaling protein 2 modulates purinergic calcium and ciliary beat frequency responses in airway epithelia JO - Am J Respir Cell Mol Biol VL - 27 UR - https://doi.org/10.1165/rcmb.2002-0012OC DO - 10.1165/rcmb.2002-0012OC ID - Nlend2002 ER - TY - JOUR AU - Fragoso, M. A. AU - Fernandez, V. AU - Forteza, R. AU - Randell, S. H. AU - Salathe, M. AU - Conner, G. E. PY - 2004 DA - 2004// TI - Transcellular thiocyanate transport by human airway epithelia JO - J Physiol VL - 561 UR - https://doi.org/10.1113/jphysiol.2004.071548 DO - 10.1113/jphysiol.2004.071548 ID - Fragoso2004 ER - TY - JOUR AU - Palma, M. AU - Naldini, L. PY - 2002 DA - 2002// TI - Transduction of a gene expression cassette using advanced generation lentiviral vectors JO - Methods Enzymol VL - 346 UR - https://doi.org/10.1016/S0076-6879(02)46074-0 DO - 10.1016/S0076-6879(02)46074-0 ID - Palma2002 ER - TY - JOUR AU - Zaccolo, M. AU - Pozzan, T. PY - 2002 DA - 2002// TI - Discrete microdomains with high concentration of cAMP in stimulated rat neonatal cardiac myocytes JO - Science VL - 295 UR - https://doi.org/10.1126/science.1069982 DO - 10.1126/science.1069982 ID - Zaccolo2002 ER - TY - JOUR AU - Ostrowski, L. E. AU - Hutchins, J. R. AU - Zakel, K. AU - O'Neal, W. K. PY - 2003 DA - 2003// TI - Targeting expression of a transgene to the airway surface epithelium using a ciliated cell-specific promoter JO - Mol Ther VL - 8 UR - https://doi.org/10.1016/S1525-0016(03)00221-1 DO - 10.1016/S1525-0016(03)00221-1 ID - Ostrowski2003 ER - TY - JOUR AU - Salathe, M. AU - Bookman, R. J. PY - 1999 DA - 1999// TI - Mode of Ca2+ action on ciliary beat frequency in single ovine airway epithelial cells JO - J Physiol VL - 520 UR - https://doi.org/10.1111/j.1469-7793.1999.00851.x DO - 10.1111/j.1469-7793.1999.00851.x ID - Salathe1999 ER - TY - JOUR AU - Harvey, P. R. AU - Tarran, R. AU - Garoff, S. AU - Myerburg, M. M. PY - 2011 DA - 2011// TI - Measurement of the airway surface liquid volume with simple light refraction microscopy JO - Am J Respir Cell Mol Biol VL - 45 UR - https://doi.org/10.1165/rcmb.2010-0484OC DO - 10.1165/rcmb.2010-0484OC ID - Harvey2011 ER - TY - JOUR AU - Celli, B. R. AU - MacNee, W. AU - Force, A. E. T. PY - 2004 DA - 2004// TI - Standards for the diagnosis and treatment of patients with COPD: a summary of the ATS/ERS position paper JO - Eur Respir J VL - 23 UR - https://doi.org/10.1183/09031936.04.00014304 DO - 10.1183/09031936.04.00014304 ID - Celli2004 ER - TY - JOUR AU - Martorana, P. A. AU - Lunghi, B. AU - Lucattelli, M. AU - Cunto, G. AU - Beume, R. AU - Lungarella, G. PY - 2008 DA - 2008// TI - Effect of roflumilast on inflammatory cells in the lungs of cigarette smoke-exposed mice JO - BMC Pulm Med VL - 8 UR - https://doi.org/10.1186/1471-2466-8-17 DO - 10.1186/1471-2466-8-17 ID - Martorana2008 ER - TY - JOUR AU - Sanz, M. J. AU - Cortijo, J. AU - Taha, M. A. AU - Cerda-Nicolas, M. AU - Schatton, E. AU - Burgbacher, B. AU - Klar, J. AU - Tenor, H. AU - Schudt, C. AU - Issekutz, A. C. PY - 2007 DA - 2007// TI - Roflumilast inhibits leukocyte-endothelial cell interactions, expression of adhesion molecules and microvascular permeability JO - Br J Pharmacol VL - 152 UR - https://doi.org/10.1038/sj.bjp.0707428 DO - 10.1038/sj.bjp.0707428 ID - Sanz2007 ER - TY - JOUR AU - Grootendorst, D. C. AU - Gauw, S. A. AU - Verhoosel, R. M. AU - Sterk, P. J. AU - Hospers, J. J. AU - Bredenbroker, D. AU - Bethke, T. D. AU - Hiemstra, P. S. AU - Rabe, K. F. PY - 2007 DA - 2007// TI - Reduction in sputum neutrophil and eosinophil numbers by the PDE4 inhibitor roflumilast in patients with COPD JO - Thorax VL - 62 UR - https://doi.org/10.1136/thx.2006.075937 DO - 10.1136/thx.2006.075937 ID - Grootendorst2007 ER - TY - JOUR AU - Dunkern, T. R. AU - Feurstein, D. AU - Rossi, G. A. AU - Sabatini, F. AU - Hatzelmann, A. PY - 2007 DA - 2007// TI - Inhibition of TGF-beta induced lung fibroblast to myofibroblast conversion by phosphodiesterase inhibiting drugs and activators of soluble guanylyl cyclase JO - Eur J Pharmacol VL - 572 UR - https://doi.org/10.1016/j.ejphar.2007.06.036 DO - 10.1016/j.ejphar.2007.06.036 ID - Dunkern2007 ER - TY - JOUR AU - Lagente, V. AU - Martin-Chouly, C. AU - Boichot, E. AU - Martins, M. A. AU - Silva, P. M. PY - 2005 DA - 2005// TI - Selective PDE4 inhibitors as potent anti-inflammatory drugs for the treatment of airway diseases JO - Mem Inst Oswaldo Cruz VL - 100 UR - https://doi.org/10.1590/S0074-02762005000900023 DO - 10.1590/S0074-02762005000900023 ID - Lagente2005 ER - TY - JOUR AU - Dinavahi, S. S. AU - Nyayapathy, S. AU - Perumal, Y. AU - Dharmarajan, S. AU - Viswanadha, S. PY - 2014 DA - 2014// TI - Combined inhibition of PDE4 and PI3Kdelta modulates the inflammatory component involved in the progression of chronic obstructive pulmonary disease JO - Drug Res (Stuttg) VL - 64 ID - Dinavahi2014 ER - TY - JOUR AU - Fabbri, L. M. AU - Calverley, P. M. AU - Izquierdo-Alonso, J. L. AU - Bundschuh, D. S. AU - Brose, M. AU - Martinez, F. J. PY - 2009 DA - 2009// TI - Roflumilast in moderate-to-severe chronic obstructive pulmonary disease treated with longacting bronchodilators: two randomised clinical trials JO - Lancet VL - 374 UR - https://doi.org/10.1016/S0140-6736(09)61252-6 DO - 10.1016/S0140-6736(09)61252-6 ID - Fabbri2009 ER - TY - JOUR AU - Calverley, P. M. AU - Rabe, K. F. AU - Goehring, U. M. AU - Kristiansen, S. AU - Fabbri, L. M. AU - Martinez, F. J. PY - 2009 DA - 2009// TI - Roflumilast in symptomatic chronic obstructive pulmonary disease: two randomised clinical trials JO - Lancet VL - 374 UR - https://doi.org/10.1016/S0140-6736(09)61255-1 DO - 10.1016/S0140-6736(09)61255-1 ID - Calverley2009 ER - TY - JOUR AU - Wanner, A. AU - Salathe, M. AU - O'Riordan, T. G. PY - 1996 DA - 1996// TI - Mucociliary clearance in the airways JO - Am J Respir Crit Care Med VL - 154 UR - https://doi.org/10.1164/ajrccm.154.6.8970383 DO - 10.1164/ajrccm.154.6.8970383 ID - Wanner1996 ER - TY - JOUR AU - Ransford, G. A. AU - Fregien, N. AU - Qiu, F. AU - Dahl, G. AU - Conner, G. E. AU - Salathe, M. PY - 2009 DA - 2009// TI - Pannexin 1 Contributes to ATP Release in Airway Epithelia JO - Am J Respir Cell Mol Biol VL - 41 UR - https://doi.org/10.1165/rcmb.2008-0367OC DO - 10.1165/rcmb.2008-0367OC ID - Ransford2009 ER - TY - JOUR AU - Nlend, M. C. AU - Schmid, A. AU - Sutto, Z. AU - Ransford, G. A. AU - Conner, G. E. AU - Fregien, N. AU - Salathe, M. PY - 2007 DA - 2007// TI - Calcium-mediated, purinergic stimulation and polarized localization of calcium-sensitive adenylyl cyclase isoforms in human airway epithelia JO - FEBS Lett VL - 581 UR - https://doi.org/10.1016/j.febslet.2007.06.015 DO - 10.1016/j.febslet.2007.06.015 ID - Nlend2007 ER - TY - JOUR AU - Lambert, J. A. AU - Raju, S. V. AU - Tang, L. P. AU - McNicholas, C. M. AU - Li, Y. AU - Courville, C. A. AU - Farris, R. F. AU - Coricor, G. E. AU - Smoot, L. H. AU - Mazur, M. M. PY - 2014 DA - 2014// TI - Cystic fibrosis transmembrane conductance regulator activation by roflumilast contributes to therapeutic benefit in chronic bronchitis JO - Am J Respir Cell Mol Biol VL - 50 UR - https://doi.org/10.1165/rcmb.2013-0228OC DO - 10.1165/rcmb.2013-0228OC ID - Lambert2014 ER - TY - JOUR AU - Milara, J. AU - Armengot, M. AU - Banuls, P. AU - Tenor, H. AU - Beume, R. AU - Artigues, E. AU - Cortijo, J. PY - 2012 DA - 2012// TI - Roflumilast N-oxide, a PDE4 inhibitor, improves cilia motility and ciliated human bronchial epithelial cells compromised by cigarette smoke in vitro JO - Br J Pharmacol VL - 166 UR - https://doi.org/10.1111/j.1476-5381.2012.01929.x DO - 10.1111/j.1476-5381.2012.01929.x ID - Milara2012 ER - TY - JOUR AU - Milara, J. AU - Serrano, A. AU - Peiro, T. AU - Artigues, E. AU - Gavalda, A. AU - Miralpeix, M. AU - Morcillo, E. J. AU - Cortijo, J. PY - 2013 DA - 2013// TI - Aclidinium inhibits cigarette smoke-induced lung fibroblast-to-myofibroblast transition JO - Eur Respir J VL - 41 UR - https://doi.org/10.1183/09031936.00017712 DO - 10.1183/09031936.00017712 ID - Milara2013 ER - TY - JOUR AU - Wyatt, T. A. AU - Forget, M. A. AU - Adams, J. M. AU - Sisson, J. H. PY - 2005 DA - 2005// TI - Both cAMP and cGMP are required for maximal ciliary beat stimulation in a cell-free model of bovine ciliary axonemes JO - Am J Physiol Lung Cell Mol Physiol VL - 288 UR - https://doi.org/10.1152/ajplung.00107.2004 DO - 10.1152/ajplung.00107.2004 ID - Wyatt2005 ER - TY - JOUR AU - Benedetto, G. AU - Magnus, C. J. AU - Gray, P. T. A. AU - Mehta, A. PY - 1991 DA - 1991// TI - Calcium regulation of ciliary beat frequency in human respiratory epithelium in vitro JO - J Physiol London VL - 439 UR - https://doi.org/10.1113/jphysiol.1991.sp018659 DO - 10.1113/jphysiol.1991.sp018659 ID - Benedetto1991 ER - TY - JOUR AU - Salathe, M. AU - Pratt, M. M. AU - Wanner, A. PY - 1993 DA - 1993// TI - Cyclic AMP-dependent phosphorylation of a 26 kD axonemal protein in ovine cilia isolated from small tissue pieces JO - Am J Respir Cell Mol Biol VL - 9 UR - https://doi.org/10.1165/ajrcmb/9.3.306 DO - 10.1165/ajrcmb/9.3.306 ID - Salathe1993 ER - TY - JOUR AU - Seybold, Z. V. AU - Mariassy, A. T. AU - Stroh, D. AU - Kim, C. S. AU - Gazeroglu, H. AU - Wanner, A. PY - 1990 DA - 1990// TI - Mucociliary interaction in vitro: effects of physiological and inflammatory stimuli JO - J Appl Physiol VL - 68 UR - https://doi.org/10.1063/1.346668 DO - 10.1063/1.346668 ID - Seybold1990 ER - TY - JOUR AU - Cantin, A. M. AU - Bilodeau, G. AU - Ouellet, C. AU - Liao, J. AU - Hanrahan, J. W. PY - 2006 DA - 2006// TI - Oxidant stress suppresses CFTR expression JO - Am J Physiol Cell Physiol VL - 290 UR - https://doi.org/10.1152/ajpcell.00070.2005 DO - 10.1152/ajpcell.00070.2005 ID - Cantin2006 ER - TY - JOUR AU - Pezzulo, A. A. AU - Starner, T. D. AU - Scheetz, T. E. AU - Traver, G. L. AU - Tilley, A. E. AU - Harvey, B. G. AU - Crystal, R. G. AU - McCray, P. B. AU - Zabner, J. PY - 2011 DA - 2011// TI - The air-liquid interface and use of primary cell cultures are important to recapitulate the transcriptional profile of in vivo airway epithelia JO - Am J Physiol Lung Cell Mol Physiol VL - 300 UR - https://doi.org/10.1152/ajplung.00256.2010 DO - 10.1152/ajplung.00256.2010 ID - Pezzulo2011 ER - TY - JOUR AU - Leopold, P. L. AU - O'Mahony, M. J. AU - Lian, X. J. AU - Tilley, A. E. AU - Harvey, B. G. AU - Crystal, R. G. PY - 2009 DA - 2009// TI - Smoking is associated with shortened airway cilia JO - PLoS One VL - 4 UR - https://doi.org/10.1371/journal.pone.0008157 DO - 10.1371/journal.pone.0008157 ID - Leopold2009 ER - TY - JOUR AU - Mata, M. AU - Sarria, B. AU - Buenestado, A. AU - Cortijo, J. AU - Cerda, M. AU - Morcillo, E. J. PY - 2005 DA - 2005// TI - Phosphodiesterase 4 inhibition decreases MUC5AC expression induced by epidermal growth factor in human airway epithelial cells JO - Thorax VL - 60 UR - https://doi.org/10.1136/thx.2004.025692 DO - 10.1136/thx.2004.025692 ID - Mata2005 ER - TY - JOUR AU - Kreda, S. M. AU - Nguyen, T. AU - Moussa, L. AU - Alonso-Galicia, M. AU - Qian, M. AU - Freire, J. PY - 2014 DA - 2014// TI - Roflumilast Inhibits Il-13-Induced Mucous Metaplasia In Airway Epithelium JO - Am J Respir Crit Care Med VL - 189 ID - Kreda2014 ER - TY - JOUR AU - Tannheimer, S. L. AU - Wright, C. D. AU - Salmon, M. PY - 2012 DA - 2012// TI - Combination of roflumilast with a beta-2 adrenergic receptor agonist inhibits proinflammatory and profibrotic mediator release from human lung fibroblasts JO - Respir Res VL - 13 UR - https://doi.org/10.1186/1465-9921-13-28 DO - 10.1186/1465-9921-13-28 ID - Tannheimer2012 ER -