Fig. 2
VBP15 Improves Mitotic Asynchrony in Asthmatic Human Airway Epithelia: Compared with wounded non-asthmatic epithelial cultures, wounded asthmatic epithelial cultures at +48 h showed a more even distribution of BrdU+ cells among the cell cycle phases (i.e., G1/G0, S, and G2/M) consistent with mitotic asynchrony (Left Panel). Pulse exposures of asthmatic epithelial cultures to VBP15 improved cell cycle synchrony as shown by normalization of the percentage of mitotic cells in each cell cycle phase although to a lesser extent than for dexamethasone (DEX)-exposed epithelial cultures. Statistical comparisons of the percentage of BrdU+ cells in G1/G0 among conditions are shown (Right Panel). Experiments were conducted in triplicate in N = 3 donors per group. (*p < 0.05 vs. normal vehicle, # p < 0.05 vs. asthma vehicle)