Fig. 1

Scheme. An allergic inflammation was assessed of sensitization with 10 μg ovalbumin (OVA) and 1 mg aluminum hydroxide (alum) by intraperinoeal (i.p.) injection and thereafter challenged with 50 μg OVA intranasally (i.n.) or PBS as control. Thereafter an intranasal administration with 20 µg poly(I:C) together with 2 µg LPS (TLR3 and TLR4 agonists) or PBS as control were given during four consecutive days. In some experiments an injection of 0.1 mg infliximab i.p. were given one hour before the TLR-agonist administration