Skip to main content
Fig. 4 | Respiratory Research

Fig. 4

From: Alveolar macrophages support interferon gamma-mediated viral clearance in RSV-infected neonatal mice

Fig. 4

Neonates demonstrate dose dependent LM activation and viral clearance. Balb/c mice were infected with RSV L19 at 5–7 days of age and treated with i.n. IFNγ (16 or 60 ng/g) or PBS on 1, 3, and 5 dpi. Luminex was used to quantify IFNγ in BALF (a) and % of original weight was calculated from baseline litter weights (b). Lungs were collected for flow cytometry to analyze the % of CD11c + CD11b- cells expressing MHC class II+ (c) and viral titers using H & E plaque assay (d). # and * represent significant differences between pups treated with 16 and 60 ng/g compared to PBS treated pups, respectively. ^ indicates significant differences between pups treated with 16 vs. 60 ng/g of IFNγ using a 2-way ANOVA with Bonferroni post-test; p < 0.05

Back to article page