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Fig. 3 | Respiratory Research

Fig. 3

From: Alveolar macrophages support interferon gamma-mediated viral clearance in RSV-infected neonatal mice

Fig. 3

Age-dependent IFNγ pharmacokinetics result in differential AM activation. AUCs were determined for uninfected pup and adult BALB/c mice following a single i.n. dose of IFNγ (16 ng/g) through intense sampling from LD over 48 h (a). Biologically, this translated to significantly greater activation of AMs (b) in adults beginning at 8 h and continuing through 48 and 24 h, respectively. Data represent ≥ 3 mice per group and 2 separate experiments. * Indicates significant differences based on a 2-way ANOVA with a Bonferroni post-test, between groups at the indicated time points; p < 0.5

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