Fig. 1
From: The lung response to ozone is determined by age and is partially dependent on toll-Like receptor 4
Age-related effects of O3 on antioxidant and neuropeptide gene expression in the lung. BALB/c mice of varying age, from 1 to 6 weeks, were exposed to FA or O3 for 3 h. Expression of MT1 (a), NRF2 (b), HMOX1 (c) and CGRP (d) was analyzed in the lungs by real-time qPCR. Data are normalized to GAPDH and presented as mean ± SEM (n = 3-6 mice/group). *: p < 0.05, compared with age-matched FA-exposed controls; #: p < 0.05, compared with 1-week old group; $: p < 0.05, compared to all other age groups. MT1: metallothionein-1, NRF2: Nuclear factor (erythroid-derived 2)-like2, HMOX1: Heme oxygenase-1, CGRP: Calcitonin gene-related peptide