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Fig. 6 | Respiratory Research

Fig. 6

From: Activation of Src-dependent Smad3 signaling mediates the neutrophilic inflammation and oxidative stress in hyperoxia-augmented ventilator-induced lung injury

Fig. 6

SIS3 and Src-deficient mice ameliorated hyperoxia-augmented lung stretch-mediated lung damage and hypoxemia. a Histological examination (×400, n = 5 per group), b Transmission electron microscopy (×6000, n = 3 per group), c lung injury scores, and d PaO2/FiO2 were from the nonventilated control mice and those subjected to a tidal volume of 30 mL/kg for 4 h with room air or hyperoxia (n = 5 per group). SIS3 2-mg/kg was given intraperitoneally 1 h before ventilation. Apoptotic cells are identified by asterisks. Highly condensed and fragmented heterochrmatin of bronchial epithelial cells indicates apoptosis. *P < 0.05 versus the nonventilated control mice with room air; † P < 0.05 versus all other groups. Scale bars represent 20 μm. FiO2 = fraction of inspired oxygen

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