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Fig. 1 | Respiratory Research

Fig. 1

From: Activation of Src-dependent Smad3 signaling mediates the neutrophilic inflammation and oxidative stress in hyperoxia-augmented ventilator-induced lung injury

Fig. 1

SIS3 and Src-deficient mice reduced hyperoxia-augmented lung stretch-induced ventilator-induced lung injury. The effects of administering SIS3 or Src heterozygous knockout on a EBD analysis, b lung wet-to-dry-weight ratio, c BAL fluid total protein, d neutrophil counts, e MPO activity, and f MIP-2 secretion in BAL fluid were from the lungs of nonventilated control mice and those subjected to a tidal volume of 30 mL/kg (VT 30) for 4 h with room air or hyperoxia (n = 5 per group). SIS3 2-mg/kg was administered intraperitoneally 1 h before ventilation. *P < 0.05 versus the nonventilated control mice with room air; † P < 0.05 versus all other groups. BAL = bronchoalveolar lavage; EBD = Evans blue dye; MIP-2 = macrophage inflammatory protein-2; MPO = myeloperoxidase; O2 = mice with hyperoxia; RA = mice with room air; SIS3 = specific inhibitor of Smad3; Src+/− = Src-deficient mice

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Respiratory Research

ISSN: 1465-993X

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