Skip to main content
Fig. 6 | Respiratory Research

Fig. 6

From: Inhaled carbon monoxide protects time-dependently from loss of hypoxic pulmonary vasoconstriction in endotoxemic mice

Fig. 6

Pressure differences determining arterial and venous fractions of pulmonary vascular resistance during hypoxic ventilation; a. Pressure drop representing the arterial resistance (PAP-PCP = pulmonary artery pressure - pulmonary capillary pressure) during hypoxic ventilation (1%O2) in lungs obtained from saline-treated controls (open bars) and from LPS-treated mice (black bars) after exposure to air or to 50 ppm CO for 18 h. Arterial resistance during hypoxia was decreased in LPS-treated mice, which was prevented by exposure to 50 ppm CO for 18 h. b. Pressure drop representing the venous resistance (PCP-LAP = pulmonary capillary pressure - left atrial pressure, with LAP = 2 mmHg) during hypoxic ventilation in lungs obtained from saline-treated controls (open bars) and from LPS-treated mice (black bars) after exposure to air or to 50 ppm CO for 18 h. No CO- or LPS-induced alterations in venous resistance during hypoxic ventilation were found. Data are presented as mean ± SD; n = 6–8 per group; *p < 0.05 vs. (saline/air 18 h); # < 0.05 vs. (LPS/CO 18 h)

Back to article page