Impaired cardiac and peripheral hemodynamic responses to inhaled β2-agonist in cystic fibrosis

Respiratory Research

Table 3 Cardiac hemodynamics

	Minutes after albuterol
	Baseline	30 min	60 min
Variable
Cardiac output (L/min)
F(1, 47)=15.72, p=0.0002; F(2, 96)=4.02, p=0.021
CF	4.9±0.3 (0.38)	5.2±0.3 (0.72)	5.2±0.4 (0.88)
CTL	5.5±0.3^†	6.2±0.3*	6.7±0.3*
Cardiac index (L/min/m²)
F(1, 47)=6.11, p=0.0172; F(2, 96)=4.29, p=0.0165
CF	2.9±0.2 (0.06)	3.0±0.2 (0.45)	3.1±0.2 (0.64)
CTL	3.0±0.1^†	3.4±0.1	3.7±0.2*
Stroke volume (mL)
F(1, 47)=27.79, p<0.0001; F(2, 96)=2.01, p=0.139
CF	59±5 (0.76)	62±6 (0.82)	60±6 (1.15)
CTL	74±3*^†	82±5*	89±5*
Stroke volume index (mL/m²)
F(1, 47)=20.74, p<0.0001; F(2, 96)=2.28, p=0.108
CF	34±3 (0.66)	36±3 (0.68)	35±3 (1.01)
CTL	41±2*^†	45±3*	49±3*
Cardiac power (L/min∙mm Hg)
F(1, 47)=20.90, p<0.0001; F(2, 96)=2.49, p=0.088
CF	401±27 (0.46)	386±23 (0.90)	415±29 (0.96)
CTL	466±27^†	505±26*	554±27*
Cardiac power index (L/min∙mm Hg/m²)
F(1, 47)=13.14, p=0.0007; F(2, 96)=3.12, p=0.048
CF	234±15 (0.26)	225±11 (0.76)	242±16 (0.81)
CTL	252±13^†	275±13*	301±13*
Stroke work (mL∙mm Hg)
F(1, 47)=35.98, p<0.001; F(2, 96)=1.55, p=0.218
CF	4786±384 (0.80)	4464±331 (1.09)	4763±463 (1.21)
CTL	6269±345*^†	6610±401*	7334±405*
Stroke work index (mL∙mm Hg/m²)
F(1, 47)=32.59, p<0.001; F(2, 96)=1.92, p=0.1530
CF	2707±184 (0.77)	2567±147 (1.02)	2741±234 (1.09)
CTL	3423±176*^†	3630±217*	4024±217*

Data presented as means±SEM. CF cystic fibrosis (n=18); CTL healthy individuals (n=30); Contained within parentheses are effect sizes (Cohen’s d) between CF and CTL; F-statistics from two-way ANOVA with repeated measures for fixed effects shown for participant (CF and CTL) and condition (baseline, 30 min, 60 min), respectively; *CF vs. CTL, p<0.05; ^†baseline vs. 60 min, p<0.05

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