Table 3 The range of each analyte measured in bronchoalveolar lavage (BAL) and bronchoabsorptive matrix exudate in this study compared to the data range of the analytes found in BAL samples from smokers [35–45], BAL samples from COPD subjects [35, 39, 40, 42, 46–51] and serum samples from smokers [39, 52–56] and serum samples from COPD subjects [39, 48, 57–60] found in literature. All data are pg/mL
From: Bronchoabsorption; a novel bronchoscopic technique to improve biomarker sampling of the airway
| Â | Range in current study | Range in literature | ||||
|---|---|---|---|---|---|---|
Analyte | BAL | Exudate | BAL (smokers) | BAL (COPD) | Serum (smokers) | Serum (COPD) |
CCL2 | 11.7–1168.7 | 170.0–1131.2 | 4–200 | 0–150 | 0–500 | 0–600 |
CCL4 | 40.7–69.1 | 171.7–406.7 | 2–23 | No data | No data | No data |
CCL5 | 3.1–32.3 | 25.1–60.3 | 1–120 | 1–100 | 0–15 | 0–40 |
CXCL1 | 103–742.7 | 11741.4–128091.4 | 0–10000 | 0–20 | No data | 0–50 |
CXCL8 | 8.3–56.5 | 460.4–5395.7 | 2–141.3 | 121–2500 | 0–300 | 1–1780 |
CXCL9 | 96.3–117.5 | 1018.3–3082 | 0–800 | 0–1000 | 0–1000 | 0–1500 |
CXCL10 | 3.5–26.9 | 151.3–2393.4 | 0–175 | 0–180 | 147–2541 | 147–2541 |
IL-1β | 2.2–9.6 | 16.2–523.7 | 1–20 | 0–210 | 9–15 | 2.1–28.2 |
IL-6 | 1.9–5.3 | 25–943 | 1–10 | 0–40 | 5–11 | 1.2–33.8 |
VEGF | 7.2–30.6 | 317.3–1199.7 | 0–300 | 0–130 | 0–76 | 151–310 |
MMP-8 | 163.3–1344.3 | 7799–101084.7 | 16–2330 | No data | 7000–19000 | No data |
MMP-9 | 1128.9–6571.2 | 3500.9–119543.9 | 0–5000 | 17.7–8820 | 0–6500 | 0–19000 |