Table 1 Effect of CLP-sepsis and various experimental interventions on severity of peritonitis
Animal/Treatment Group | Peritoneal Lavage Parameter | ||||||
|---|---|---|---|---|---|---|---|
Sham | CLP | ||||||
Protein | Bacterial load | Total Cells | Protein | Bacterial load | Total Cells | ||
(mg/mL) | (10 4  CFU/mL) | (10 7 /mL) | (mg/mL) | (10 4  CFU/mL) | (10 7 /mL) | ||
Wild-Type | Â | Â | Â | Â | Â | Â | |
|  | DMSO | 0.6 ± 0.1 | 0.0 ± 0.0 | 0.07 ± 0.01 | 2.2 ± 0.2 | 5.4 ± 0.7 | 3.6 ± 0.2 |
|  | Q-VD | 0.7 ± 0.1 | 0.0 ± 0.0 | 0.07 ± 0.01 | 2.1 ± 0.1 | 5.4 ± 1.1 | 2.5 ± 0.1 * |
NADPH oxidase deficient | Â | Â | Â | Â | Â | ||
|  | p47phox−/− | 1.0 ± 0.3 | 0.3 ± 0.3 | 0.12 ± 0.04 | 2.4 ± 0.5 | 5.9 ± 1.2 | 3.3 ± 0.3 |
|  | gp91−/− | 1.1 ± 0.4 | 0.2 ± 0.3 | 0.15 ± 0.05 | 2.6 ± 0.7 | 6.4 ± 1.5 | 2.9 ± 0.4 |