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Fig. 8 | Respiratory Research

Fig. 8

From: Bidirectional role of IL-6 signal in pathogenesis of lung fibrosis

Fig. 8

Blockade of IL-6 at early fibrotic stage of BLM-injured lung ameliorates lung fibrosis. Mice were divided into two groups: BLM + control IgG group, and BLM + anti-IL-6 group. a Body weight (BW) of BLM-instilled mice with or without IL-6-neutralizing antibody treatment. Time-dependent change in BW is expressed as percentage of BW of each mouse just before BLM instillation. *P < 0.05, significantly different from BLM + control IgG group at each indicated time point by Student’s t-test. Data represent mean ± S.E.M. (n = 6). b Survival rate of BLM-instilled mice with or without IL-6-neutralizing antibody treatment. Data represent mean ± S.E.M. (n = 12). c Effect of IL-6-neutralizing antibody on BLM-induced histopathological change in the lung. Lung sections from each group at 14 dpi were stained with Masson’s trichrome to visualize fibrotic lesions. d Semi-quantitative measurement of lung fibrotic change. Six mice in each group were used. Data are shown as mean ± S.E.M. of twelve sections (two sections/mouse). *P < 0.05, significantly different from BLM + control IgG group by Student’s t-test

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