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Fig. 7 | Respiratory Research

Fig. 7

From: Bidirectional role of IL-6 signal in pathogenesis of lung fibrosis

Fig. 7

Blockade of IL-6 at early inflammatory stage of BLM-injured lung accelerates lung fibrosis. Mice were divided into four groups: PBS group, BLM group, BLM + control IgG group, and BLM + anti-IL-6 group. a Effect of IL-6-neutralizing antibody on BLM-induced histopathological changes in the lung. Lung sections from each group at 7 and 14 dpi were stained with Masson’s trichrome to visualize fibrotic lesions. b Semi-quantitative measurement of lung fibrotic change. Eight mice in each group were used. Data are shown as scores of sixteen sections (two sections/mouse). Bars represent median values. *P < 0.05, significantly different from value of BLM-treated lung (ANOVA followed by Tukey’s test). The difference between the two groups (7 and 14 dpi of BLM) was statistically significant (#) by Student’s t-test for unpaired values. n.s., no significant difference

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