Fig. 6
From: Bidirectional role of IL-6 signal in pathogenesis of lung fibrosis
Blockade of IL-6 at early inflammatory stage of BLM-injured lung enhances apotosis of type 2 pneumocytes and alveolitis. Mice were divided into four groups: PBS group, BLM group, BLM + control IgG group, and BLM + anti-IL-6 group. a Apoptotic type 2 pneumocytes were elucidated by counting YO-PRO-1-permeable cells at 3 dpi. Data are shown as mean ± S.E.M. of twenty sections from each individual (n = 5). *P < 0.05, significantly different from value of BLM-treated lung (ANOVA followed by Tukey’s test). b Effect of IL-6-neutralizing antibody on change in number of infiltrated cells into the lung. Data are shown as mean ± S.E.M. (n = 5). *P < 0.05, significantly different from value of BLM-treated lung (ANOVA followed by Tukey’s test)