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Table 6 Change in oxidative stress gene expression related to changes in Forced Expiratory Volume in 1 second (FEV1) in response to single dose MCh challenge (mean ± SD). P-value for pre vs. post sulforaphane

From: Sulforaphane improves the bronchoprotective response in asthmatics through Nrf2-mediated gene pathways

 

Gene Expression (% change from baseline)

GST1

NQO1

GCLM

Decreased FEV1 response to MCh

−6.11 ± 27.0

−73.1 ± 255.4

−19.2 ± 40.6

p = 0.67

p = 0.23

p = 0.03

Increased FEV1 response to MCh

11.8 ± 56.0

141.9 ± 283.7

32.4 ± 75.0

p = 0.38

p = 0.047

p = 0.58

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Respiratory Research

ISSN: 1465-993X

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