Fig. 2

Negative correlation between the changes (%) resulting from sulforaphane (SF) administration on: a. bronchodilation (BD) and on b. bronchoprotection (BP) in asthmatic subjects, and the effects of sulforaphane administration on the reduction of FEV₁ caused by MCh challenge. a: There was a significant negative correlation between the changes in BD and the changes in FEV₁ (r² = 0.13, p = 0.01). As the decrease in FEV₁ with MCh challenge (airway narrowing) became larger with administration of sulforaphane, the BD response became smaller. b: There was a significant negative correlation between the changes in BP and the changes in FEV₁ (r² = 0.26, p = 0.0005). As the decrease in FEV₁ with MCh challenge (airway narrowing) became larger with administration of sulforaphane, the BP response became smaller. The Mean control FEV₁ was 2.7 ± 0.7 L, and a single MCh challenge caused a reduction in FEV₁ by 0.78 ± 0.3 L. We further made the widely accepted assumption that the reproducibility of FEV₁ values was 0.1 L, so that x-axis changes in Fig. 2a and b between −0.1 and +0.1 L were considered as no effect