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Fig. 4 | Respiratory Research

Fig. 4

From: Altered protease and antiprotease balance during a COPD exacerbation contributes to mucus obstruction

Fig. 4

Mucus hydration increases mucin degradation. a Sputum was obtained at the onset of a COPD exacerbation and diluted 1:60 and 1:100. Mucin degradation was measured after incubation for 6 h at 37 °C with or without NE 0.02 mg/mL. Mucin concentration of the control at 1:60 was set to 100 %. b Sputum was obtained at the onset of a COPD exacerbation and diluted 1:60 and 1:80. Mucin degradation was measured after incubation for 6 h at 37 °C with cathepsin G 100 μU/μL diluted 1:25 and 1:10. Mucin concentration of the control was set at 1:60 and 1:80 was set to 100 %

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