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Fig. 4 | Respiratory Research

Fig. 4

From: Increased FGF1-FGFRc expression in idiopathic pulmonary fibrosis

Fig. 4

Overexpression of FGF1 and FGF-receptors FGFR1, FGFR2, FGFR3 and FGFR4 in hyperplastic bronchioles in remodelled areas of dense fibrosis in idiopathic pulmonary fibrosis (IPF) lungs. a Immunohistochemistry for KRT5 (a1,2), α-SMA (a3,4), FGFR1 (a5,6), FGF1 (a7,8) and FGFR2 (a9,10) in serial sections of IPF lung tissue. Moderate immunostaining for FGFR1, but very strong staining for FGF1and FGFR2 is observed in basal and luminal bronchial epithelial cells of abnormal, hyperplastic bronchioles (indicated by KRT5-staining) surrounded by dense fibrotic regions. b Representative immunohistochemistry for KRT5 (b1,2), FGF1 (b3,4), α-SMA (b5,6), FGFR3 (b7,8) and FGFR4 (b9,10) in serial sections of IPF lung tissue. In IPF, bronchial epithelial cells of abnormal bronchioles in areas of bronchiolization and dense fibrosis indicate robust expression of FGF1, FGFR3 and FGFR4. Scale bars: a1,3,5,7,9 (250 μm); a2,4,6,8,10 (50 μm), b1,3,5,7,9 (250 μm), b2,4,6,8,10 (50 μm)

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