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Fig. 9 | Respiratory Research

Fig. 9

From: Hyperoxia-induced methylation decreases RUNX3 in a newborn rat model of bronchopulmonary dysplasia

Fig. 9

RUNX3 protein and mRNA levels over time in AT2 cells after inhibitor treatment. RUNX3 protein expression in AT2 cells was detected by Western blot at different time points after JMJD3 (20 μg/L), DZNep (1 μmol/L) or 5-Aza-CdR (5 μmol/L) treatment (a). In the model group, RUNX3 protein in AT2 cells was up-regulated after 48 h with JMJD3 or DZNep, but not 5-Aza-CdR, treatment (b). As detected by real-time PCR, RUNX3 mRNA in AT2 cells of the model group was up-regulated after 72 h treatment with JMJD3, DZNep or 5-Aza-Cd (c). 24, 48, 72 h: 24, 48 and 72 h after inhibitor treatment. *P < 0.05 vs. control group; #P < 0.05 vs. model group, n = 4

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