Fig. 8
From: Hyperoxia-induced methylation decreases RUNX3 in a newborn rat model of bronchopulmonary dysplasia
Binding between H3K27me3/EZH2 and the RUNX3 promoter in AT2 cells. As determined by ChIP, binding levels between H3K27me3 (a) or EZH2 (b) and the RUNX3 promoter region were higher in AT2 cells after 14 days of hyperoxia compared to the control group. Gene locus 1: RUNX3 promoter region −5407 ~ −5142 bp; 2: RUNX3 promoter region −5407 ~ −5215 bp; 3: RUNX3 promoter region −5407 ~ −5142 bp. *P < 0.05 vs. control group, n = 10