Association of 25-Hydroxyvitamin D status and genetic variation in the vitamin D metabolic pathway with FEV1 in the Framingham Heart Study

Table 5 Association of the most statistically significant SNP per gene with the rate of change in FEV₁ in FHS and in the meta-analyzed replication cohorts

Gene	Gene-based P Value	Chr	Total SNPs in gene	Best SNP	Position	Coded Allele^a	Freq	FHS (N = 3,230)			Meta-analyzed replication cohorts (N = 7,246)
Gene	Gene-based P Value	Chr	Total SNPs in gene	Best SNP	Position	Coded Allele^a	Freq	β	SE	P	β	SE	P
CYP27B1	0.02248	12	5	rs10877013	56451352	T	0.30	−1.3	0.5	0.02	−0.4	0.5	0.40
CYP2R1	0.04417	11	15	rs11819875	14873873	G	0.18	−1.9	0.7	0.004	−1.0	0.6	0.09

Adjusted for: baseline age, sex, height, smoking pattern over follow-up and its interaction with time, baseline smoking pack-years, and the first two principal components for genetic ancestry
Chr chromosome, SNP single nucleotide polymorphism, β beta coefficient for SNP x time effect, SE standard error, P P-value
^aCoded allele and frequency for the Framingham Heart Study (FHS). All effect estimates presented in terms of FHS coded allele. Coded allele frequencies between FHS and replication cohorts were nearly identical

ISSN: 1465-993X