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Fig. 3 | Respiratory Research

Fig. 3

From: A flavanone from Baccharis retusa (Asteraceae) prevents elastase-induced emphysema in mice by regulating NF-κB, oxidative stress and metalloproteinases

Fig. 3

Expression of MMP-9, MMP-12 and TIMP-1 in lung tissue. The mean and SE of the number of cells in the lung parenchyma that were positive for TIMP-1 a, MMP-9 b and MMP-12 c. Representative photomicrographs of lung parenchyma immunostained for TIMP-1 d-f, MMP-9 g-i and MMP-12 j-l. The number of positive cells for TIMP-1, MMP-9 and MMP-12 increased in animals that received elastase e, h and k compared with control animals d, g and j. Interestingly, sakuranetin increased the number of TIMP-1-positive cells and reduced the number of MMP-9- and MMP-12-positive cells in the elastase-treated groups f, i and l; see arrows). *p < 0.001 compared with the SAL+Ve and SAL+SK groups; **p < 0.05 compared with the ELA+Ve group

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Respiratory Research

ISSN: 1465-993X

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