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Fig. 4 | Respiratory Research

Fig. 4

From: Epigenetics of Notch1 regulation in pulmonary microvascular rarefaction following extrauterine growth restriction

Fig. 4

Histone modifications of the Notch1 gene promoter in rats at 3 and 9 weeks. a Schematic illustration showing the different enrichment peak (red bar) detected by Medip-chip in the distal promoter of the Notch1 gene and the region analyzed by bisulfite sequencing (BS) (blue bar). ChIP-qPCR analysis of regions proximal to the transcription start site are also indicated (yellow bar). The distribution pattern of four histone modifications at three sites in the proximal promoter (<−1500 bp) of Notch1 at (b) 3 weeks and (c) 9 weeks, analyzed by ChIP/real-time qPCR. Data are presented as mean ± SEM. (PVECs from 9 rats of each group were assessed). *P < 0.05

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Respiratory Research

ISSN: 1465-993X

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