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Table 4 Associations between biomarker levels and clinical parameters

From: Accelerated extracellular matrix turnover during exacerbations of COPD

  FEV1 %pred FVC %pred 6MWD
C3M −0.118 −0.201 −0.350** (−0.311*)
C4M −0.149 −0.161 −0.289* (−0.252)
C6M −0.096 −0.226 −0.403** (−0.354**)
ELM7 −0.090 −0.149 −0.178
EL-NE −0.039 −0.106 −0.186
VCANM −0.0004 −0.080 −0.067
Pro-C3 0.345* (0.320*) 0.313* (0.305*) 0.055
P4NP 7S −0.086 −0.193 −0.269* (−0.230)
Pro-C6 0.023 −0.046 −0.153
  1. Results are presented as univariate correlation coefficients (r) for each marker. In brackets are given multivariate correlation coefficients for markers showing significant r. The multivariate linear regression analysis included age, gender, BMI, smoking pack years, and smoking status as additional explanatory variables. Significance levels: *P <0.05, **P <0.01. FEV1, forced expiratory volume in one second; %pred, percentage of predicted value; FVC, forced vital capacity; 6MWD, 6 min walking distance