Respiratory Research

Table 3 Estimated nonparametric relative effects showing intergroup differences as probabilities

From: Neutrophil extracellular trap (NET) formation characterises stable and exacerbated COPD and correlates with airflow limitation

	Smoking controls omitted					Smoking controls included
	FEV1	Non-activated neutrophils	NET-forming neutrophils	NETs	NET covered area	FEV1	Non-activated neutrophils	NET-forming neutrophils	NETs	NET covered area
Exacerbated COPD	0.27908	0.52941	0.56471	0.72680	0.75098	0.20931	0.53676	0.56225	0.75686	0.79363
Stable COPD	0.41690	0.45798	0.50280	0.49020	0.47479	0.31968	0.46534	0.50035	0.53081	0.52276
Smoking controls						0.76254	0.47794	0.50735	0.38408	0.36808
non-smoking controls	0.83725	0.52941	0.43137	0.28693	0.28431	0.74559	0.53676	0.42892	0.33137	0.32402
COPD grades 3/4	0.27669	0.51089	0.56100	0.64670	0.64089	0.20752	0.51825	0.55855	0.68192	0.68818
COPD grades 1/2	0.60784	0.41830	0.43137	0.41503	0.43682	0.47222	0.42565	0.42892	0.45425	0.47794
Smokong controls						0.76254	0.47794	0.50735	0.38408	0.36808
Non-smoking controls	0.83725	0.52941	0.43137	0.28693	0.28431	0.74559	0.53676	0.42892	0.33137	0.32402

Evaluation of study data with a closed testing procedure performing multiple hypothesis tests simultaneously, significant endpoints in bold. Summary of estimated nonparametric relative effects of tested variables with and without inclusion of the smoking controls. Estimated relative effects measure the probability that a value obtained from one experimental group is larger than a value randomly chosen from the whole trial including the controls. The procedure yields similar conclusions about the significance of differences between study groups and between COPD severity groups, irrespective of whether smoking controls are excluded or included

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ISSN: 1465-993X

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