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Fig. 6 | Respiratory Research

Fig. 6

From: RETRACTED ARTICLE: Protective role of p120-catenin in maintaining the integrity of adherens and tight junctions in ventilator-induced lung injury

Fig. 6

The role of p120, PP2 and Y27632 in mechanical ventilator-induced lung injury in mice. Some mice were injected with the complex composed of liposome and p120 siRNA through retinal vein plexus to delete p120. Some mice were pretreated with PP2 (2 μg/kg) or Y27632 (2 mg/kg) for 1 h before exposure to high tidal volume mechanical ventilation (MV) for 2 h. Mice without ventilation was regarded as control group. (a) Successful transfection of p120 siRNA was confirmed by western blot of lung homogenates in mice. (b) RhoA activity in p120 knockout group (KO). (c) Effects of p120 depletion on the junction proteins. Loss of p120 could cause the degradation of E-cadherin, occludin. (d) Effects of pretreatment with PP2 or Y27632 on junction proteins in mice lung tissue after mechanical ventilation. (e, h) Lung W/D ratio. (f, i) IL-6 level in BAL fluid. (g, j) TNF-α level in BAL fluid. Quantitative analysis: *p < 0.05 versus control group, +p < 0.05 versus MV group. #p < 0.05 versus p120 KO (knockout) and MV group. Experiments were repeated at least three times

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