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Table 4 Healthcare resource utilization during the 12 month post-index period

From: Comparative effectiveness of budesonide/formoterol combination and fluticasone/salmeterol combination among chronic obstructive pulmonary disease patients new to controller treatment: a US administrative claims database study

   

Estimate*

95% CI

P-value

BFC (N = 3,697)

FSC (N = 3,697)

Lower

Upper

COPD-related healthcare resource utilization

COPD-related inpatient hospitalizations

          

Number of patients with ≥1 event (n, %)

228

6.2%

 

255

6.9%

 

0.91

0.76

1.10

0.3466

Number of events (mean, SD, median)1

1.3

1.1

1.0

1.2

0.7

1.0

0.10

−0.08

0.32

0.3016

Length of stay per patient (mean, SD, median)1

7.0

9.1

4.0

7.2

10.5

4.0

0.04

−0.96

1.21

0.9485

COPD-related ICU stays

          

Number of patients with ≥1 event (n, %)

24

0.6%

 

32

0.9%

 

0.73

0.43

1.25

0.2564

Number of events (mean, SD, median)1

1.3

0.7

1.0

1.1

0.3

1.0

0.13

−0.33

0.85

0.6391

Length of stay per patient (mean, SD, median)1

1.8

2.0

1.0

2.7

8.5

1.0

0.16

−0.66

1.73

0.7661

COPD-related ED visits

          

Number of patients with ≥1 event (n, %)

453

12.3%

 

438

11.8%

 

1.08

0.93

1.24

0.3123

Number of events (mean, SD, median)1

1.4

0.9

1.0

1.4

0.9

1.0

0.02

−0.11

0.18

0.7462

COPD-related outpatient/office visits

          

Number of patients with ≥1 event (n, %)

3,047

82.4%

 

3,072

83.1%

 

0.93

0.82

1.05

0.2500

Number of events (mean, SD, median)1

9.6

11.9

5.0

10.0

12.8

5.0

−0.26

−0.63

0.14

0.1966

All-cause healthcare resource utilization

All-cause inpatient hospitalizations

          

Number of patients with ≥1 event (n, %)

1,131

30.6%

 

1,178

31.9%

 

0.98

0.89

1.09

0.7422

Number of events (mean, SD, median)1

1.9

1.5

1.0

2.0

1.7

1.0

0.04

−0.06

0.14

0.4678

Length of stay per patient (mean, SD, median)1

9.3

14.6

5.0

11.2

17.2

5.0

−0.10

−0.44

0.25

0.5528

All-cause ICU stays

          

Number of patients with ≥1 event (n, %)

220

6.0%

 

241

6.5%

 

0.95

0.78

1.15

0.5631

Number of events (mean, SD, median)1

1.2

0.6

1.0

1.3

0.7

1.0

0.00

−0.18

0.21

0.9906

Length of stay per patient (mean, SD, median)1

2.0

5.5

1.0

1.9

4.2

1.0

0.00

−0.22

0.26

0.9910

All-cause ED visits

          

Number of patients with ≥1 event (n, %)

1,012

27.4%

 

1,003

27.1%

 

1.05

0.94

1.16

0.4070

Number of events (mean, SD, median)1

1.6

1.4

1.0

1.7

1.7

1.0

0.02

−0.08

0.14

0.6778

All-cause outpatient/office visits

          

Number of patients with ≥1 event (n, %)

3,679

99.5%

 

3,669

99.2%

 

1.59

0.88

2.88

0.1274

Number of events (mean, SD, median)1

33.1

30.7

25.0

34.9

32.3

27.0

0.03

−0.44

0.52

0.8925

  1. *: Odds ratio from logistic regression is used for dichotomous variables (0 vs.1); Odds ratio from ordinal logistic regression is used for ordinal variables (0 vs. 1 vs. 2+); mean difference from negative binomial models is used for count variables. Statistical comparisons are comparing BFC to FSC (reference group); i.e., Mean diff = mean (BFC)-mean(FSC) and OR = Odds(BFC)/Odds(FSC). Model covariates include: Sum of inpatient hospital stays >5 days (0 vs. 1), LTRA use (0, 1, 2+), geographic region, Peripheral vascular disease / atherosclerosis (0 vs. 1), index prescribing physician specialty, and analogous pre-index variable.
  2. 1: Including only patients with at least one event; length of stay defined as the number of days from admission to discharge. Same date admission and discharge were counted as one.