Table 3 COPD medication use – adherence to index medication and prescription fills for other respiratory medication classes during the post-index period

Adherence to index medication

Number of fills for index medication (including index fill) (mean, SD)

3.8

3.2

4.0

3.4

−0.20

−0.34

−0.05

0.0071

Patients with only the index fill (n, %)

1,252

33.9%

1208

32.7%

0.95

0.87

1.03

0.2197

Patients with 2 fills (n, %)

563

15.2%

575

15.6%

Patients with 3 fills (n, %)

393

10.6%

398

10.8%

Patients with 4 or more fills (n, %)

1,489

40.3%

1516

41.0%

Proportion of days covered with index medication (mean, SD)

0.33

0.28

0.34

0.29

−0.01

−0.02

0.00

0.0914

COPD respiratory medications (number of patients with at least one fill)

ICS monotherapy use (n, %)

220

6.0%

230

6.2%

0.94

0.78

1.14

0.5250

LAMA monotherapy use (n, %)

1,188

32.1%

1,226

33.2%

0.95

0.86

1.05

0.3232

LABA monotherapy use (n, %)

87

2.4%

78

2.1%

1.12

0.82

1.53

0.4807

Roflumilast (n, %)

23

0.6%

18

0.5%

1.23

0.66

2.29

0.5052

Theophylline use (n, %)

123

3.3%

111

3.0%

1.09

0.84

1.42

0.5120

SABA (n, %)

1,815

49.1%

1,845

49.9%

0.96

0.87

1.05

0.3550

SAMA (n, %)

169

4.6%

178

4.8%

0.95

0.77

1.18

0.6591

SABA/SAMA combination use (n, %)

656

17.7%

646

17.5%

1.03

0.91

1.16

0.6465

OCS monotherapy use (n, %)

1,628

44.0%

1,544

41.8%

1.09

0.99

1.20

0.0674

LTRA monotherapy use (n, %)

498

13.5%

429

11.6%

1.03

0.86

1.25

0.7316

Omalizumab use (n, %)

7

0.2%

5

0.1%

1.30

0.41

4.10

0.6556

Antibiotics use (n, %)

2,686

72.7%

2,667

72.1%

1.02

0.92

1.13

0.7239