Figure 1

Noggin haploinsufficiency protects mice from bleomycin-induced lung fibrosis. (A) Representative images of lungs from WT and Nog ^+/LacZ mice, 4 weeks after PBS or bleomycin instillation. (Hematoxylin-Eosin staining; bar = 200 μm) (B) Ashcroft score from WT mice (PBS n = 20, BLM n = 25) and Nog ^+/LacZ mice (PBS n = 5, BLM n = 14), 4 weeks after bleomycin instillation. (C) Hydroxyproline content of right lungs from WT mice (PBS n = 5, BLM n = 5) and Nog ^+/LacZ mice (PBS n = 3, BLM n = 8), 4 weeks after bleomycin instillation. (D) Pulmonary compliance of WT mice (PBS n = 12, BLM n = 16) and Nog ^+/LacZ mice (PBS n = 7, BLM n = 10), 4 weeks after bleomycin instillation. (*p < 0.05 by Sidak multiple comparison test post 2-way ANOVA; data presented as mean and SEM).