Figure 6From: Cigarette smoke inhibits BAFF expression and mucosal immunoglobulin A responses in the lung during influenza virus infection Cigarette smoke (CS) exposure prior to influenza infection causes decreased Aicda in lung B cells. Mice were exposed to room air (RA) or CS for 3 months and then infected with influenza virus or vehicle control. Lung B cells were isolated on day 7 after infection. The relative mRNA levels of (A) Aicda, (B) BAFF receptor (BAFF-R), (C) transmembrane activator and calcium modulator cyclophilin ligand interactor (TACI) and (D) B cell maturation antigen (BCMA) in lung B cells are shown (n = 5 mice/group). RA + Flu, RA-exposed mice with influenza virus infection; CS + Flu, CS-exposed mice with influenza virus infection; *P < 0.05.Back to article page