Table 1 Activity and selectivity of PXS-4728A in vitro
From: Effects of an anti-inflammatory VAP-1/SSAO inhibitor, PXS-4728A, on pulmonary neutrophil migration
Assay | IC 50 | Â |
Recombinant human VAP-1/SSAO (AOC3) | 5 nM | Â |
Gonadal fat tissue homogenate; mouse, rat, dog, rabbit | <10 nM | Â |
Assay | IC 50 | Selectivity |
Recombinant diamine oxidase (AOC1) | 12.0 μM | >2000x |
Recombinant retina specific amine oxidase (AOC2) | 2.76 μM | >500x |
Purified lysyl oxidase from lung fibroblasts | 13.2 μM | >2000x |
Recombinant lysyl oxidase like 2 | 10.4 μM | >2000x |
Recombinant monoamine oxidase A | >100 μM | >2000x |
Recombinant monoamine oxidase B | 2.7 μM | >500x |
Recombinant lysine demethylase | >10 μM | >2000x |