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Figure 8 | Respiratory Research

Figure 8

From: Effects of an anti-inflammatory VAP-1/SSAO inhibitor, PXS-4728A, on pulmonary neutrophil migration

Figure 8

Inhibition of inflammation during viral induced asthma exacerbation. Allergic airways disease was established with house dust mite (HDM) sensitization followed by HDM challenge. RV1b infection was superimposed on the allergic mice to induce an exacerbation and results analysed 24 hours post infection. PXS-4728A reduced (A) total BALF neutrophils and (B) significantly reduced airways hyperreactivity to methacholine challenge in ventilated mice as of 2.5−1. N = 8 per group for AHR and N = 4 per group for BALF; ***p < 0.001 over HDM/vehicle/RV. AHR analysed by two-way ANOVA with Newman-Keuls Multiple Comparison Test.

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