Figure 6

Inhibition of inflammation during Klebsiella pneumonia infection. Mice were inoculated intranasally with 0.05 mL of ~10⁵ – 10⁷ input CFU of Klebsiella pneumoniae. Inhibition of VAP-1/SSAO dampened (A) total leukocyte as well as (B) neutrophil migration into the airway spaces and increased bacterial load (C). (D) Although bacterial counts were higher in the VAP-1/SSAO inhibited group, survival was not affected;comparison in the survival of dexamethasone treated animals to PXS-4728A was of p < 0.0018. N = 8 per group for the BALF and bacterial counts, N = 10 for survival; **p < 0.01, ***p < 0.001 over vehicle.