Inhibition of LPS induced inflammation. LPS caused an increase in total number of cells and neutrophils in the BALF, as measured 6 and 24 hours after the insult. Pre-treatment with PXS-4728A (VAP-1/SSAO inhibitor) concentration-dependently reduced the influx of (A) total cells and (B) neutrophils at 6 hours. Pre-treatment with 4 mg/kg of PXS-4728A (VAP-1/SSAO inhibitor), followed by a repeat treatment of 6 mg/kg at 6 hours reduced the influx of (C) total cells and (D) neutrophils. N = 6-12 per group; *p < 0.05, **p < 0.01, ***p < 0.001 over vehicle.