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Table 1 Significantly regulated TJ-related genes in response to CdCl 2 treatment in human airway epithelial ALI cultures (fold change ≥ 1.5, p value < 0.05)

From: Tight junction disruption by cadmium in an in vitro human airway tissue model

Gene name

Gene description

Biological function

Group 1 (30 μM)

Group 2 (100 μM)

Fold change

p value

Fold change

p value

Up-regulated

ICAM1

Intercellular adhesion molecule 1

Cell surface receptors

  

13.89

0.000114

CRB3

Crumbs homolog 3 (Drosophila)

Cell surface receptors

  

3.95

0.000507

CLDN1

Claudin 1

Cell surface receptors

  

2.99

0.000232

CLDN4

Claudin 4

Cell surface receptors

  

2.57

0.012412

OCLN

Occludin

Cell surface receptors

  

2.53

0.000418

ARHGEF2

Rho/rac guanine nucleotide exchange factor 2

G Protein signaling

  

2.15

0.007405

CLDN2

Claudin 2

Cell surface receptors

  

2.14

0.045285

TJP1

Tight junction protein 1 (Zona occludens-1)

Junction interacting proteins

  

2.13

0.00451

SMURF1

SMAD specific E3 ubiquitin protein ligase 1

Cytoskeleton Regulator/G Protein Signaling

  

1.71

0.005857

CLDN12

Claudin 12

Cell surface receptors

  

1.65

0.008749

JAM3

Junctional adhesion molecule 3

Junction interacting proteins

  

1.62

0.015438

AMOTL1

Angiomotin like 1

Junction interacting proteins/Cytoskeleton regulation

1.99

0.009748

  

HCLS1

Hematopoietic cell-specific Lyn substrate 1

Junction interacting proteins

1.62

0.017181

  

Down-regulated

MPDZ

Multiple PDZ domain protein

Junction interacting proteins

  

−7.35

0.000001

PTEN

Phosphatase and tensin homolog

Protein kinase signaling

  

−4.22

0

ICAM2

Intercellular adhesion molecule 2

Cell surface receptors

  

−4.01

0.019093

CGN

Cingulin

Junction interacting proteins

  

−3.74

0.007739

CDK4

Cyclin-dependent kinase 4

G Protein signaling

  

−3.58

0.012422

CLDN16

Claudin 16

Cell surface receptors

  

−3.15

0.000298

MAGI1

Membrane associated guanylate kinase, WW and PDZ domain containing 1

Junction interacting proteins/Protein kinase signaling

  

−3.13

0.000032

CLDN8

Claudin 8

Cell surface receptors

  

−2.77

0.000306

CLDN2

Claudin 2

Cell surface receptors

−1.96

0.03226

  

GNAI1

Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1

G Protein signaling

  

−2.70

0.000373

VAPA

VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa

Junction interacting proteins

  

−2.20

0.000723

TJAP1

Tight junction associated protein 1 (peripheral)

Junction interacting proteins

  

−2.20

0.028018

ASH1L

Ash1 (absent, small, or homeotic)-like (Drosophila)

Cytoskeleton Regulator

  

−2.14

0.000877

SYMPK

Symplekin

Junction interacting proteins

  

−2.07

0.040784

CSNK2A2

Casein kinase 2, alpha prime polypeptide

Protein kinase signaling

  

−1.97

0.004506

CSDA

Cold shock domain protein A

Junction interacting proteins/Cytoskeleton regulator

  

−1.73

0.000039

MPP6

Membrane protein, palmitoylated 6 (MAGUK p55 subfamily member 6)

Protein kinase signaling

  

−1.71

0.0007

MLLT4

Myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4

Junction interacting proteins

  

−1.60

0.014185

CSNK2A1

Casein kinase 2, alpha 1 polypeptide

Protein kinase signaling

  

−1.55

0.002999