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Table 1 Significantly regulated TJ-related genes in response to CdCl 2 treatment in human airway epithelial ALI cultures (fold change ≥ 1.5, p value < 0.05)

From: Tight junction disruption by cadmium in an in vitro human airway tissue model

Gene name Gene description Biological function Group 1 (30 μM) Group 2 (100 μM)
Fold change p value Fold change p value
Up-regulated
ICAM1 Intercellular adhesion molecule 1 Cell surface receptors    13.89 0.000114
CRB3 Crumbs homolog 3 (Drosophila) Cell surface receptors    3.95 0.000507
CLDN1 Claudin 1 Cell surface receptors    2.99 0.000232
CLDN4 Claudin 4 Cell surface receptors    2.57 0.012412
OCLN Occludin Cell surface receptors    2.53 0.000418
ARHGEF2 Rho/rac guanine nucleotide exchange factor 2 G Protein signaling    2.15 0.007405
CLDN2 Claudin 2 Cell surface receptors    2.14 0.045285
TJP1 Tight junction protein 1 (Zona occludens-1) Junction interacting proteins    2.13 0.00451
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 Cytoskeleton Regulator/G Protein Signaling    1.71 0.005857
CLDN12 Claudin 12 Cell surface receptors    1.65 0.008749
JAM3 Junctional adhesion molecule 3 Junction interacting proteins    1.62 0.015438
AMOTL1 Angiomotin like 1 Junction interacting proteins/Cytoskeleton regulation 1.99 0.009748   
HCLS1 Hematopoietic cell-specific Lyn substrate 1 Junction interacting proteins 1.62 0.017181   
Down-regulated
MPDZ Multiple PDZ domain protein Junction interacting proteins    −7.35 0.000001
PTEN Phosphatase and tensin homolog Protein kinase signaling    −4.22 0
ICAM2 Intercellular adhesion molecule 2 Cell surface receptors    −4.01 0.019093
CGN Cingulin Junction interacting proteins    −3.74 0.007739
CDK4 Cyclin-dependent kinase 4 G Protein signaling    −3.58 0.012422
CLDN16 Claudin 16 Cell surface receptors    −3.15 0.000298
MAGI1 Membrane associated guanylate kinase, WW and PDZ domain containing 1 Junction interacting proteins/Protein kinase signaling    −3.13 0.000032
CLDN8 Claudin 8 Cell surface receptors    −2.77 0.000306
CLDN2 Claudin 2 Cell surface receptors −1.96 0.03226   
GNAI1 Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 G Protein signaling    −2.70 0.000373
VAPA VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa Junction interacting proteins    −2.20 0.000723
TJAP1 Tight junction associated protein 1 (peripheral) Junction interacting proteins    −2.20 0.028018
ASH1L Ash1 (absent, small, or homeotic)-like (Drosophila) Cytoskeleton Regulator    −2.14 0.000877
SYMPK Symplekin Junction interacting proteins    −2.07 0.040784
CSNK2A2 Casein kinase 2, alpha prime polypeptide Protein kinase signaling    −1.97 0.004506
CSDA Cold shock domain protein A Junction interacting proteins/Cytoskeleton regulator    −1.73 0.000039
MPP6 Membrane protein, palmitoylated 6 (MAGUK p55 subfamily member 6) Protein kinase signaling    −1.71 0.0007
MLLT4 Myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4 Junction interacting proteins    −1.60 0.014185
CSNK2A1 Casein kinase 2, alpha 1 polypeptide Protein kinase signaling    −1.55 0.002999