From: Tight junction disruption by cadmium in an in vitro human airway tissue model
Gene name | Gene description | Biological function | Group 1 (30 μM) | Group 2 (100 μM) | ||
---|---|---|---|---|---|---|
Fold change | p value | Fold change | p value | |||
Up-regulated | ||||||
ICAM1 | Intercellular adhesion molecule 1 | Cell surface receptors | Â | Â | 13.89 | 0.000114 |
CRB3 | Crumbs homolog 3 (Drosophila) | Cell surface receptors | Â | Â | 3.95 | 0.000507 |
CLDN1 | Claudin 1 | Cell surface receptors | Â | Â | 2.99 | 0.000232 |
CLDN4 | Claudin 4 | Cell surface receptors | Â | Â | 2.57 | 0.012412 |
OCLN | Occludin | Cell surface receptors | Â | Â | 2.53 | 0.000418 |
ARHGEF2 | Rho/rac guanine nucleotide exchange factor 2 | G Protein signaling | Â | Â | 2.15 | 0.007405 |
CLDN2 | Claudin 2 | Cell surface receptors | Â | Â | 2.14 | 0.045285 |
TJP1 | Tight junction protein 1 (Zona occludens-1) | Junction interacting proteins | Â | Â | 2.13 | 0.00451 |
SMURF1 | SMAD specific E3 ubiquitin protein ligase 1 | Cytoskeleton Regulator/G Protein Signaling | Â | Â | 1.71 | 0.005857 |
CLDN12 | Claudin 12 | Cell surface receptors | Â | Â | 1.65 | 0.008749 |
JAM3 | Junctional adhesion molecule 3 | Junction interacting proteins | Â | Â | 1.62 | 0.015438 |
AMOTL1 | Angiomotin like 1 | Junction interacting proteins/Cytoskeleton regulation | 1.99 | 0.009748 | Â | Â |
HCLS1 | Hematopoietic cell-specific Lyn substrate 1 | Junction interacting proteins | 1.62 | 0.017181 | Â | Â |
Down-regulated | ||||||
MPDZ | Multiple PDZ domain protein | Junction interacting proteins |  |  | −7.35 | 0.000001 |
PTEN | Phosphatase and tensin homolog | Protein kinase signaling |  |  | −4.22 | 0 |
ICAM2 | Intercellular adhesion molecule 2 | Cell surface receptors |  |  | −4.01 | 0.019093 |
CGN | Cingulin | Junction interacting proteins |  |  | −3.74 | 0.007739 |
CDK4 | Cyclin-dependent kinase 4 | G Protein signaling |  |  | −3.58 | 0.012422 |
CLDN16 | Claudin 16 | Cell surface receptors |  |  | −3.15 | 0.000298 |
MAGI1 | Membrane associated guanylate kinase, WW and PDZ domain containing 1 | Junction interacting proteins/Protein kinase signaling |  |  | −3.13 | 0.000032 |
CLDN8 | Claudin 8 | Cell surface receptors |  |  | −2.77 | 0.000306 |
CLDN2 | Claudin 2 | Cell surface receptors | −1.96 | 0.03226 |  |  |
GNAI1 | Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 | G Protein signaling |  |  | −2.70 | 0.000373 |
VAPA | VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa | Junction interacting proteins |  |  | −2.20 | 0.000723 |
TJAP1 | Tight junction associated protein 1 (peripheral) | Junction interacting proteins |  |  | −2.20 | 0.028018 |
ASH1L | Ash1 (absent, small, or homeotic)-like (Drosophila) | Cytoskeleton Regulator |  |  | −2.14 | 0.000877 |
SYMPK | Symplekin | Junction interacting proteins |  |  | −2.07 | 0.040784 |
CSNK2A2 | Casein kinase 2, alpha prime polypeptide | Protein kinase signaling |  |  | −1.97 | 0.004506 |
CSDA | Cold shock domain protein A | Junction interacting proteins/Cytoskeleton regulator |  |  | −1.73 | 0.000039 |
MPP6 | Membrane protein, palmitoylated 6 (MAGUK p55 subfamily member 6) | Protein kinase signaling |  |  | −1.71 | 0.0007 |
MLLT4 | Myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4 | Junction interacting proteins |  |  | −1.60 | 0.014185 |
CSNK2A1 | Casein kinase 2, alpha 1 polypeptide | Protein kinase signaling |  |  | −1.55 | 0.002999 |