Table 5 Top up- and down-regulated genes common to both alveolar macrophages and buffy coats from ARDS patients as compared to controls

S100A12

S100 calcium binding protein A12

49.43

5.56

IL1R2

Interleukin 1 receptor, type II

35.5

9.66

CD177

CD177 molecule

34.32

44.84

MGAM

Maltase-glucoamylase (alpha-glucosidase)

26.87

3.34

OLFM4

Olfactomedin 4

25.24

28.11

MMP8

Matrix metallopeptidase 8

17.41

31.96

ANXA3

Annexin A3

17.18

3.67

MRVI1

Murine retrovirus integration site 1 homolog

17.11

3.51

DYSF

Dysferlin

16.47

14.24

CXCR1

Chemokine (C-X-C) receptor 1

16.06

4.66

PROK2

Prokineticin 2

15.09

2.79

MMP25

Matrix metallopeptidase 25

14.59

12.52

METTL7B

Methyltransferase-like 7B

11.88

6.4

DEFA1

Defensin, alpha 1

11.43

23.52

GPR97

G protein-coupled receptor 97

11.07

9.29

F5

Coagulation factor V (proaccelerin)

9.79

6.45

LRG1

Leucine-rich alpha-2-glycoprotein 1

9.08

4.89

ADAM8

ADAM metallopeptidase domain 8

8.94

2.73

CSF3R

Colony stimulating factor 3 receptor

8.85

7.88

ARAP3

ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3

8.75

4.51

RASSF2

Ras association (RalGDS/AF-6) domain family member 2

8.51

8.01

PADI2

Peptidyl arginine deiminase, type II

7.86

12.49

FGF13

Fibroblast growth factor 13

7.35

5.91

RNF175

Ring finger protein 175

7.17

2.96

PRKCB

Protein kinase C, beta

7.01

7.02

PXN

Paxillin

6.34

6.01

VNN1

Vanin 1

6.07

10.24

GAS7

Growth arrest-specific 7

5.28

3.5

TSNAX

Translin-associated factor X

5.26

4.42

IFITM2

Interferon induced transmembrane protein 2 (1-8D)

5.21

9.44

GGT1

Gamma-glutamyltransferase 1

4.55

7.3

SIGLEC5

Sialic acid binding Ig-like lectin 5

4.45

7.57

BASP1

Brain abundant, membrane attached signal protein 1

4.2

2.8

MXD1

MAX dimerization protein 1

3.93

3.17

LMNB1

Lamin B1

3.78

4.13

CR1

Complement component (3b/4b) receptor 1

3.62

4.51

PSTPIP2

Proline-serine-threonine phosphatase interacting protein 2

3.37

2.9

GGTLC1

Gamma-glutamyltransferase light chain 1

3.28

3.3

PGS1

Phosphatidylglycerophosphate synthase 1

3.22

5.24

S100A8

S100 calcium binding protein A8

2.97

5.98

AQP9

Aquaporin 9

2.83

4.11

SLC22A4

Solute carrier family 22 (organic cation/ergothioneine transporter), member 4

2.83

3.17

IL17RA

Interleukin 17 receptor A

2.71

3.32

HDAC4

Histone deacetylase 4

2.66

4.25

ITGAM

Integrin, alpha M

2.58

2.47

AGTRAP

Angiotensin II receptor-associated protein

2.22

5.61

SMAP2

Small ArfGAP2

2.22

4.96

HLX

H2.0-like homeobox

2.17

4.84

IMMP2L

IMP2 inner mitochondrial membrane peptidase-like

−2.06

−3.08

L3MBTL3

l(3)mbt-like 3 (Drosophila)

−2.06

−2.34

CD3G

CD3g molecule, gamma (CD3-TCR complex)

−2.35

−2.47

PIGL

Phosphatidylinositol glycan anchor biosynthesis, class L

−2.4

−2.6

PLA2G16

Phospholipase A2, group XVI

−2.68

−2.3

CCDC50

Coiled-coil domain containing 50

−2.71

−4.71

ICA1L

Islet cell autoantigen 1,69 kDa-like

−3.07

−3.74

ZNF124

Zinc finger protein 124

−3.11

−4.54

WWOX

WW domain containing oxidoreductase

−3.39

−3.81

EPB41L4A

Erythrocyte membrane protein band 4.1 like 4A

−3.41

−10.19

RORA

RAR-related orphan receptor A

−4.17

−7.89

YES1

v-yes-1 Yamaguchi sarcoma viral oncogene homolog 1

−4.19

−4.55

RORA

RAR-related orphan receptor A

−4.21

−3.43

ZNF846

Zinc finger protein 846

−4.54

−2.31

SASH1

SAM and SH3 domain containing 1

−4.73

−4.29

ENPP5

Ectonucleotide pyrophosphatase/phosphodiesterase 5 (putative function)

−5.72

−4.99

JAKMIP2

Janus kinase and microtubule interacting protein 2

−5.77

−2.77

TCEA3

Transcription elongation factor A (SII), 3

−7.57

−2.77