Network of treatments connected by studies for each outcome of interest. A: change from baseline FEV1, L; B: annual rate of exacerbations; C: change from baseline SGRQ Total score. Note: All stated nominal doses are mcg. Connecting lines represent studies included in the model that directly compare the two treatments. The thickness of the line is proportional to the number of studies comparing the two treatments. BDP = beclomethasone dipropionate, BID = twice daily, BUD = budesonide, FORM = formoterol, FF = fluticasone furoate, FP = fluticasone propionate, MMF = mometasone furoate, QD = once daily, SAL = salmeterol, THEO = theophylline, TIO = tiotropium, VI = vilanterol.