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Figure 5 | Respiratory Research

Figure 5

From: Denatonium inhibits growth and induces apoptosis of airway epithelial cells through mitochondrial signaling pathways

Figure 5

Denatonium down-regulates the expression of the anti-apoptotic protein Bcl-2 and enhances the release of cytochrome c and Smac/DIABLO from mitochondria in 16HBE cells. A) The expression of the anti-apoptotic protein Bcl-2 was significantly reduced in 16HBE cells after treatment with denatonium for 24 h. B) In 16HBE cells treated with denatonium for 24 h, the cytochrome c and Smac/DIABLO levels in mitochondria were significantly reduced, whereas, the cytochrome c and Smac/DIABLO levels in cytosol were significantly increased (C). The figures are representative profiles of at least three experiments. (***p < 0.001).

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Respiratory Research

ISSN: 1465-993X

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