Figure 5

MMP-12 contributes to RSV-induced resriratory symptoms. Mice were killed at days 1, 3, 5, 7 and 9 post-infection, and MMP-12 was detected using ELISA. A: MMP-12 levels in BALF. B: MMP-12 levels following MMP408, a specific inhibitor of MMP-12,administration. C: Inflammatory cells in BALB/c mice. D: Inflammatory cells in nude mice. E: AHR in BALB/c mice. F: AHR in nude mice. mock: mock-infected mice group; control: mock-infected and PBS treated mice group; RSV: RSV-infected and PBS treated mice group; RSV + MMP408: RSV-infected and MMP408 treated mice group, Disease parameters were assessed on day 9 and data are representative of two independent experiments performed on 6–10 animals per group. *, p < 0.05, **, p < 0.01, ***, p < 0.001 shown comparing the control mice groups to other groups. ^, p < 0.05, ^^, p < 0.01, ^^^, p < 0.001 for RSV + PBS groups versus the RSV + MMP408 groups.