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Table 3 Dendritic cell concentrations and characteristics

From: Imbalance of dendritic cell co-stimulation in COPD

  Never-smoker (N) Smoker (S) COPD (C) S vs. N C vs. N C vs. S
n = 21 n = 21 n = 54 p-value p-value p-value
mDC (% of leukocytes) 0.19 [0.09-0.39] 0.14 [0.05-0.27] 0.15 [0.04-0.30] <0.05 <0.05 0.354
mDC (103/ml blood) 12.4 [5.0-26.5] 11.0 [3.5-29.2] 10.9 [3.6-31.2] 0.392 0.654 0.575
pDC (% of leukocytes) 0.09 [0.04-0.25] 0.08 [0.02-0.19] 0.09 [0.02-0.22] 0.595 0.740 0.749
pDC (103/ml blood) 5.5 [2.8-15.4] 7.0 [1.7-19.4] 6.4 [1.5-16.9] 0.227 0.145 0.680
ratio mDC/pDC 1.9 [1.0-4.8] 1.3 [0.7-3.6] 1.7 [0.5-5.2] 0.084 0.141 0.575
mDC surface markers       
BDCA-1 (% positive mDC) 61 [37–87] 67 [36–92] 72 [34–94] 0.505 <0.05 0.101
BDCA-3 (% positive mDC) 41 [14–77] 68 [24–100] 61 [20–99] <0.001 <0.001 0.516
CD54 (MFI) 260 [177–373] 251 [87–355] 262 [160–445] 0.651 0.354 0.097
CD86 (% positive mDC) 24 [1–70] 56 [6–77] 44 [1–92] <0.05 <0.05 0.953
PD-L1 (% positive mDC) 8 [0–31] 11 [1–66] 9 [0–41] 0.529 0.925 0.286
CCR5 (% positive mDC) 9 [0–63] 12 [0–75] 28 [0–91] 0.191 <0.01 0.200
OX40L (% positive mDC) 9 [1–91] 12 [0–32] 16 [5–72] 0.642 <0.05 <0.01
pDC surface markers       
CD54 (MFI) 316 [181–480] 351 [251–715] 287 [0–698] 0.406 0.124 <0.05
PD-L1 (% positive pDC) 35 [4–62] 36 [9–73] 23 [0–80] 0.678 < 0.05 < 0.01
  1. Parameters are displayed as median values [minimum…maximum]. Abbreviations denote: Plasmacytoid Dendritic Cell (pDC), myeloid Dendritic Cell (mDC), Blood Dendritic Cell Antigen (BDCA), Cluster of Differentiation (CD), Chemokine Receptor (CCR), Programmed Death Ligand 1 (PD-L1). The columns on the right side of the table show comparisons between the groups: Asymptomatic smokers (S), never-smokers (N), patients with COPD (C).