Figure 5From: Inhibition of HMGCoA reductase by simvastatin protects mice from injurious mechanical ventilation Effect of simvastatin on endothelial dysfunction in experimental ventilator lung inury. (A) Total protein content in BALF was used as a marker of endothelial barrier disruption by high-tidal-volume ventilation for four hours. (B) Representative immunoblotting of Vascular Endothelial (VE)-Cadherin, the structural protein of endothelial adherens junctions, in mouse lung tissue. (C) Quantification of intensity ratio of VE-Cadherin in reference to β-tubulin in lung samples. (LVt: low tidal volume; HVt: high tidal volume; NS: normal saline; Simva: Simvastatin; *denotes p < 0.05; **p < 0.01 and ***p < 0.001).Back to article page