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Figure 5 | Respiratory Research

Figure 5

From: Inhibition of HMGCoA reductase by simvastatin protects mice from injurious mechanical ventilation

Figure 5

Effect of simvastatin on endothelial dysfunction in experimental ventilator lung inury. (A) Total protein content in BALF was used as a marker of endothelial barrier disruption by high-tidal-volume ventilation for four hours. (B) Representative immunoblotting of Vascular Endothelial (VE)-Cadherin, the structural protein of endothelial adherens junctions, in mouse lung tissue. (C) Quantification of intensity ratio of VE-Cadherin in reference to β-tubulin in lung samples. (LVt: low tidal volume; HVt: high tidal volume; NS: normal saline; Simva: Simvastatin; *denotes p < 0.05; **p < 0.01 and ***p < 0.001).

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