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Figure 5 | Respiratory Research

Figure 5

From: Conditional overexpression of TGFβ1 promotes pulmonary inflammation, apoptosis and mortality via TGFβR2 in the developing mouse lung

Figure 5

TGFβ1 signaling in NB TGFβ1TG, and TGFβ1TG X TGFβR2KO mice lungs. (A) Western blot analysis showed upregulation of phospho AKT, and down regulation of ANGPT2, and pro-apoptotic proteins (BAX; cleaved caspase 3) in NB TGFβ1TG X TGFβR2KO lungs as compared to TGFβ1TG mice. (B) Densitometric analysis showed increased ANGPT1 to ANGPT2 ratio in maternal dox exposed NB TGFβ1TG X TGFβR2KO lungs as compared to TGFβTG mice. N = 3, in each group; *p < 0.05.

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