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Figure 7 | Respiratory Research

Figure 7

From: Increased constitutive αSMA and Smad2/3 expression in idiopathic pulmonary fibrosis myofibroblasts is KCa3.1-dependent

Figure 7

HLMF αSMA stress fibres are significantly attenuated by K Ca 3.1 blockers. (A) TRAM-34 dose-dependently decreased the number of actin stress fibres (NFC n = 3 and IPF n = 3, data pooled for statistical analysis). (B) ICA-17043 dose-dependently decreased the number of actin stress fibres (NFC n = 5 and IPF n = 3, data pooled for statistical analysis). No difference in response to the KCa3.1 blockers were seen between NFC and IPF donors. Results are represented as mean ± SEM *P < 0.05, **P < 0.01 (2 Way ANOVA corrected by Sidaks multiple comparisons test).

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